The most important thing to note before starting the fight is that nano-infused weapons work the best here, especially thanks to their high damage output once the build-up reaches its peak. If you don’t have a steady source of omni-cells (Jaguar or Wraith sets) then you can switch to the Starfish after you’ve used up all of your omni-cells, even for just the brief stagger that comes with it. The Starfish, while useless in stunning her outright, can still be used for staggering her at times. The rifle or flame-channeled drones (acquired from statue enemies at Gideon’s Rock) can work wonders here, and it’s up to you which one you prefer. Avoid using electrical-based weapons, as these don’t really do anything against her since most Children of the Spark members are resistant to electrical damage. Sorensen in Gateway Bravo after her questline) or the SERU Biomaster (check out a guide for getting it here) if you prefer fire weapons. Take your pick from the many nanite weapons given to you by Athena from her visions, or get either the INF-Labs Vechni (bought from Dr. Matriarch Celeste is particularly susceptible to both nano and fire damage, and as such you want to capitalize on this by wielding nano- and fire-infused weapons. Likewise, if you’ve got a nano-infused weapon, consider the Chrysalis set, as its partial bonus gives you an additional +20 nano damage. The Nano Ward set found in AID Command is particularly strong as well (check out a guide on how to acquire it here), given that you can deflect most of her incoming attacks. For the most part, anything that provides a substantial boost to elemental resistance is great, but you can also trade that off for sets that give additional bonuses for aggressive play, like the LYNX set I discussed here as well as its other contemporaries. You’ll want to equip your best gear here and now, as the fight ahead can be brutal. He then takes the Spark with him, leaving Matriarch Celeste to deal with you. Before the fight begins, you can view a cutscene of her reviving Brother Eli for a second time, setting up a third rematch with him in the near future. You’ll first find yourself at the peak of the dome, making your way down. Matriarch Celeste is found in the central dome of the Cathedral, at the very ground floor. The Sanctum you fight her is pretty expansive, but it can become very dangerous in the second phase. Her two phases are slightly different from one another, but both work on the same principles. Treat this fight like you did all the other human bosses – that is, to play aggressively and counter whenever possible, so as to keep her attacks at bay and minimize her damage output. She’s also susceptible to proper directional blocks, as both her forms rely on melee attacks that can be deflected with the proper timing. Matriarch Celeste, while incredibly augmented, is still human and shares the same weaknesses (except for electricity) as many other humans. Prepare to take on some of the most annoying enemies in the entire game here, as you’ll constantly find yourself stunned if you get hit by their brutal attacks. The Cathedral is built like a fortress, with tons of electrical weapon-wielding acolytes ready to swarm you in an instant. Following Jonah Guttenberg’s directions to get the Spark to successfully conquer the nanite swarm, you journey through Port Nixon and into the lair of the enemy itself. Matriarch Celeste is the boss waiting for you at the Inner Sanctum of the Cathedral of the Spark.
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